diff --git a/aio/content/examples/testing/src/app/demo/async-helper.spec.ts b/aio/content/examples/testing/src/app/demo/async-helper.spec.ts
index ca0239408d..8f6d340ffb 100644
--- a/aio/content/examples/testing/src/app/demo/async-helper.spec.ts
+++ b/aio/content/examples/testing/src/app/demo/async-helper.spec.ts
@@ -25,21 +25,21 @@ describe('Angular async helper', () => {
        async(() => { setTimeout(() => { actuallyDone = true; }, 0); }));
 
     it('should run async test with task', async(() => {
-      const id = setInterval(() => {
-        actuallyDone = true;
-        clearInterval(id);
-      }, 100);
-    }));
+         const id = setInterval(() => {
+           actuallyDone = true;
+           clearInterval(id);
+         }, 100);
+       }));
 
     it('should run async test with successful promise', async(() => {
-      const p = new Promise(resolve => { setTimeout(resolve, 10); });
-      p.then(() => { actuallyDone = true; });
-    }));
+         const p = new Promise(resolve => { setTimeout(resolve, 10); });
+         p.then(() => { actuallyDone = true; });
+       }));
 
     it('should run async test with failed promise', async(() => {
-      const p = new Promise((resolve, reject) => { setTimeout(reject, 10); });
-      p.catch(() => { actuallyDone = true; });
-    }));
+         const p = new Promise((resolve, reject) => { setTimeout(reject, 10); });
+         p.catch(() => { actuallyDone = true; });
+       }));
 
     // Use done. Can also use async or fakeAsync.
     it('should run async test with successful delayed Observable', (done: DoneFn) => {
@@ -48,56 +48,84 @@ describe('Angular async helper', () => {
     });
 
     it('should run async test with successful delayed Observable', async(() => {
-      const source = of (true).pipe(delay(10));
-      source.subscribe(val => actuallyDone = true, err => fail(err));
-    }));
+         const source = of (true).pipe(delay(10));
+         source.subscribe(val => actuallyDone = true, err => fail(err));
+       }));
 
     it('should run async test with successful delayed Observable', fakeAsync(() => {
-      const source = of (true).pipe(delay(10));
-      source.subscribe(val => actuallyDone = true, err => fail(err));
+         const source = of (true).pipe(delay(10));
+         source.subscribe(val => actuallyDone = true, err => fail(err));
 
-      tick(10);
-    }));
+         tick(10);
+       }));
   });
 
   describe('fakeAsync', () => {
     // #docregion fake-async-test-tick
     it('should run timeout callback with delay after call tick with millis', fakeAsync(() => {
-        let called = false;
-        setTimeout(() => { called = true; }, 100);
-        tick(100);
-        expect(called).toBe(true);
-      }));
+         let called = false;
+         setTimeout(() => { called = true; }, 100);
+         tick(100);
+         expect(called).toBe(true);
+       }));
     // #enddocregion fake-async-test-tick
 
+    // #docregion fake-async-test-tick-new-macro-task-sync
+    it('should run new macro task callback with delay after call tick with millis',
+       fakeAsync(() => {
+         function nestedTimer(cb: () => any): void { setTimeout(() => setTimeout(() => cb())); }
+         const callback = jasmine.createSpy('callback');
+         nestedTimer(callback);
+         expect(callback).not.toHaveBeenCalled();
+         tick(0);
+         // the nested timeout will also be triggered
+         expect(callback).toHaveBeenCalled();
+       }));
+    // #enddocregion fake-async-test-tick-new-macro-task-sync
+
+    // #docregion fake-async-test-tick-new-macro-task-async
+    it('should not run new macro task callback with delay after call tick with millis',
+       fakeAsync(() => {
+         function nestedTimer(cb: () => any): void { setTimeout(() => setTimeout(() => cb())); }
+         const callback = jasmine.createSpy('callback');
+         nestedTimer(callback);
+         expect(callback).not.toHaveBeenCalled();
+         tick(0, {processNewMacroTasksSynchronously: false});
+         // the nested timeout will not be triggered
+         expect(callback).not.toHaveBeenCalled();
+         tick(0);
+         expect(callback).toHaveBeenCalled();
+       }));
+    // #enddocregion fake-async-test-tick-new-macro-task-async
+
     // #docregion fake-async-test-date
     it('should get Date diff correctly in fakeAsync', fakeAsync(() => {
-        const start = Date.now();
-        tick(100);
-        const end = Date.now();
-        expect(end - start).toBe(100);
-      }));
+         const start = Date.now();
+         tick(100);
+         const end = Date.now();
+         expect(end - start).toBe(100);
+       }));
     // #enddocregion fake-async-test-date
 
     // #docregion fake-async-test-rxjs
     it('should get Date diff correctly in fakeAsync with rxjs scheduler', fakeAsync(() => {
-        // need to add `import 'zone.js/dist/zone-patch-rxjs-fake-async'
-        // to patch rxjs scheduler
-        let result = null;
-        of ('hello').pipe(delay(1000)).subscribe(v => { result = v; });
-        expect(result).toBeNull();
-        tick(1000);
-        expect(result).toBe('hello');
+         // need to add `import 'zone.js/dist/zone-patch-rxjs-fake-async'
+         // to patch rxjs scheduler
+         let result = null;
+         of ('hello').pipe(delay(1000)).subscribe(v => { result = v; });
+         expect(result).toBeNull();
+         tick(1000);
+         expect(result).toBe('hello');
 
-        const start = new Date().getTime();
-        let dateDiff = 0;
-        interval(1000).pipe(take(2)).subscribe(() => dateDiff = (new Date().getTime() - start));
+         const start = new Date().getTime();
+         let dateDiff = 0;
+         interval(1000).pipe(take(2)).subscribe(() => dateDiff = (new Date().getTime() - start));
 
-        tick(1000);
-        expect(dateDiff).toBe(1000);
-        tick(1000);
-        expect(dateDiff).toBe(2000);
-      }));
+         tick(1000);
+         expect(dateDiff).toBe(1000);
+         tick(1000);
+         expect(dateDiff).toBe(2000);
+       }));
     // #enddocregion fake-async-test-rxjs
   });
 
diff --git a/aio/content/guide/testing.md b/aio/content/guide/testing.md
index 3aacef659e..0eeb798aed 100644
--- a/aio/content/guide/testing.md
+++ b/aio/content/guide/testing.md
@@ -1266,7 +1266,8 @@ You do have to call [tick()](api/core/testing/tick) to advance the (virtual) clo
 Calling [tick()](api/core/testing/tick) simulates the passage of time until all pending asynchronous activities finish.
 In this case, it waits for the error handler's `setTimeout()`.
 
-The [tick()](api/core/testing/tick) function accepts milliseconds as a parameter (defaults to 0 if not provided). The parameter represents how much the virtual clock advances. For example, if you have a `setTimeout(fn, 100)` in a `fakeAsync()` test, you need to use tick(100) to trigger the fn callback.
+The [tick()](api/core/testing/tick) function accepts milliseconds and tickOptions as parameters, the millisecond (defaults to 0 if not provided) parameter represents how much the virtual clock advances. For example, if you have a `setTimeout(fn, 100)` in a `fakeAsync()` test, you need to use tick(100) to trigger the fn callback. The tickOptions is an optional parameter with a property called processNewMacroTasksSynchronously (defaults is true) represents whether to invoke
+new generated macro tasks when ticking.
 
 <code-example
   path="testing/src/app/demo/async-helper.spec.ts"
@@ -1276,6 +1277,22 @@ The [tick()](api/core/testing/tick) function accepts milliseconds as a parameter
 The [tick()](api/core/testing/tick) function is one of the Angular testing utilities that you import with `TestBed`.
 It's a companion to `fakeAsync()` and you can only call it within a `fakeAsync()` body.
 
+#### tickOptions
+
+<code-example
+  path="testing/src/app/demo/async-helper.spec.ts"
+  region="fake-async-test-tick-new-macro-task-sync">
+</code-example>
+
+In this example, we have a new macro task (nested setTimeout), by default, when we `tick`, the setTimeout `outside` and `nested` will both be triggered.
+
+<code-example
+  path="testing/src/app/demo/async-helper.spec.ts"
+  region="fake-async-test-tick-new-macro-task-async">
+</code-example>
+
+And in some case, we don't want to trigger the new maco task when ticking, we can use `tick(milliseconds, {processNewMacroTasksSynchronously: false})` to not invoke new maco task.
+
 #### Comparing dates inside fakeAsync()
 
 `fakeAsync()` simulates passage of time, which allows you to calculate the difference between dates inside `fakeAsync()`.
diff --git a/packages/core/test/fake_async_spec.ts b/packages/core/test/fake_async_spec.ts
index 036cabef96..ddf44dfa29 100644
--- a/packages/core/test/fake_async_spec.ts
+++ b/packages/core/test/fake_async_spec.ts
@@ -127,6 +127,31 @@ const ProxyZoneSpec: {assertPresent: () => void} = (Zone as any)['ProxyZoneSpec'
            expect(ran).toEqual(true);
          }));
 
+      it('should run new macro tasks created by timer callback', fakeAsync(() => {
+           function nestedTimer(callback: () => any): void {
+             setTimeout(() => setTimeout(() => callback()));
+           }
+           const callback = jasmine.createSpy('callback');
+           nestedTimer(callback);
+           expect(callback).not.toHaveBeenCalled();
+           tick(0);
+           expect(callback).toHaveBeenCalled();
+         }));
+
+      it('should not queue nested timer on tick with processNewMacroTasksSynchronously=false',
+         fakeAsync(() => {
+           function nestedTimer(callback: () => any): void {
+             setTimeout(() => setTimeout(() => callback()));
+           }
+           const callback = jasmine.createSpy('callback');
+           nestedTimer(callback);
+           expect(callback).not.toHaveBeenCalled();
+           tick(0, {processNewMacroTasksSynchronously: false});
+           expect(callback).not.toHaveBeenCalled();
+           flush();
+           expect(callback).toHaveBeenCalled();
+         }));
+
       it('should run queued timer only once', fakeAsync(() => {
            let cycles = 0;
            setTimeout(() => { cycles++; }, 10);
diff --git a/packages/core/testing/src/fake_async.ts b/packages/core/testing/src/fake_async.ts
index 1f84eabdc0..f515987b59 100644
--- a/packages/core/testing/src/fake_async.ts
+++ b/packages/core/testing/src/fake_async.ts
@@ -62,13 +62,54 @@ export function fakeAsync(fn: Function): (...args: any[]) => any {
  *
  * {@example core/testing/ts/fake_async.ts region='basic'}
  *
+ * @param millis, the number of millisecond to advance the virtual timer
+ * @param tickOptions, the options of tick with a flag called
+ * processNewMacroTasksSynchronously, whether to invoke the new macroTasks, by default is
+ * false, means the new macroTasks will be invoked
+ *
+ * For example,
+ *
+ * it ('test with nested setTimeout', fakeAsync(() => {
+ *   let nestedTimeoutInvoked = false;
+ *   function funcWithNestedTimeout() {
+ *     setTimeout(() => {
+ *       nestedTimeoutInvoked = true;
+ *     });
+ *   };
+ *   setTimeout(funcWithNestedTimeout);
+ *   tick();
+ *   expect(nestedTimeoutInvoked).toBe(true);
+ * }));
+ *
+ * in this case, we have a nested timeout (new macroTask), when we tick, both the
+ * funcWithNestedTimeout and the nested timeout both will be invoked.
+ *
+ * it ('test with nested setTimeout', fakeAsync(() => {
+ *   let nestedTimeoutInvoked = false;
+ *   function funcWithNestedTimeout() {
+ *     setTimeout(() => {
+ *       nestedTimeoutInvoked = true;
+ *     });
+ *   };
+ *   setTimeout(funcWithNestedTimeout);
+ *   tick(0, {processNewMacroTasksSynchronously: false});
+ *   expect(nestedTimeoutInvoked).toBe(false);
+ * }));
+ *
+ * if we pass the tickOptions with processNewMacroTasksSynchronously to be false, the nested timeout
+ * will not be invoked.
+ *
+ *
  * @publicApi
  */
-export function tick(millis: number = 0): void {
+export function tick(
+    millis: number = 0, tickOptions: {processNewMacroTasksSynchronously: boolean} = {
+      processNewMacroTasksSynchronously: true
+    }): void {
   if (fakeAsyncTestModule) {
-    return fakeAsyncTestModule.tick(millis);
+    return fakeAsyncTestModule.tick(millis, tickOptions);
   } else {
-    return tickFallback(millis);
+    return tickFallback(millis, tickOptions);
   }
 }
 
diff --git a/packages/core/testing/src/fake_async_fallback.ts b/packages/core/testing/src/fake_async_fallback.ts
index dd08df64ef..0b15a9533e 100644
--- a/packages/core/testing/src/fake_async_fallback.ts
+++ b/packages/core/testing/src/fake_async_fallback.ts
@@ -118,8 +118,11 @@ function _getFakeAsyncZoneSpec(): any {
  *
  * @publicApi
  */
-export function tickFallback(millis: number = 0): void {
-  _getFakeAsyncZoneSpec().tick(millis);
+export function tickFallback(
+    millis: number = 0, tickOptions: {processNewMacroTasksSynchronously: boolean} = {
+      processNewMacroTasksSynchronously: true
+    }): void {
+  _getFakeAsyncZoneSpec().tick(millis, null, tickOptions);
 }
 
 /**
diff --git a/packages/zone.js/lib/testing/fake-async.ts b/packages/zone.js/lib/testing/fake-async.ts
index 1c0907a232..d688705cd5 100644
--- a/packages/zone.js/lib/testing/fake-async.ts
+++ b/packages/zone.js/lib/testing/fake-async.ts
@@ -117,7 +117,9 @@ Zone.__load_patch('fakeasync', (global: any, Zone: ZoneType, api: _ZonePrivate)
    *
    * @experimental
    */
-  function tick(millis: number = 0): void { _getFakeAsyncZoneSpec().tick(millis); }
+  function tick(millis: number = 0, ignoreNestedTimeout = false): void {
+    _getFakeAsyncZoneSpec().tick(millis, null, ignoreNestedTimeout);
+  }
 
   /**
    * Simulates the asynchronous passage of time for the timers in the fakeAsync zone by
diff --git a/packages/zone.js/lib/zone-spec/fake-async-test.ts b/packages/zone.js/lib/zone-spec/fake-async-test.ts
index 9a55158f32..625b9a7763 100644
--- a/packages/zone.js/lib/zone-spec/fake-async-test.ts
+++ b/packages/zone.js/lib/zone-spec/fake-async-test.ts
@@ -72,6 +72,8 @@
     private _currentTime: number = 0;
     // Current real time in millis.
     private _currentRealTime: number = OriginalDate.now();
+    // track requeuePeriodicTimer
+    private _currentTickRequeuePeriodicEntries: any[] = [];
 
     constructor() {}
 
@@ -81,10 +83,24 @@
 
     setCurrentRealTime(realTime: number) { this._currentRealTime = realTime; }
 
-    scheduleFunction(
-        cb: Function, delay: number, args: any[] = [], isPeriodic: boolean = false,
-        isRequestAnimationFrame: boolean = false, id: number = -1): number {
-      let currentId: number = id < 0 ? Scheduler.nextId++ : id;
+    scheduleFunction(cb: Function, delay: number, options?: {
+      args?: any[],
+      isPeriodic?: boolean,
+      isRequestAnimationFrame?: boolean,
+      id?: number,
+      isRequeuePeriodic?: boolean
+    }): number {
+      options = {
+        ...{
+          args: [],
+          isPeriodic: false,
+          isRequestAnimationFrame: false,
+          id: -1,
+          isRequeuePeriodic: false
+        },
+        ...options
+      };
+      let currentId = options.id ! < 0 ? Scheduler.nextId++ : options.id !;
       let endTime = this._currentTime + delay;
 
       // Insert so that scheduler queue remains sorted by end time.
@@ -92,11 +108,14 @@
         endTime: endTime,
         id: currentId,
         func: cb,
-        args: args,
+        args: options.args !,
         delay: delay,
-        isPeriodic: isPeriodic,
-        isRequestAnimationFrame: isRequestAnimationFrame
+        isPeriodic: options.isPeriodic !,
+        isRequestAnimationFrame: options.isRequestAnimationFrame !
       };
+      if (options.isRequeuePeriodic !) {
+        this._currentTickRequeuePeriodicEntries.push(newEntry);
+      }
       let i = 0;
       for (; i < this._schedulerQueue.length; i++) {
         let currentEntry = this._schedulerQueue[i];
@@ -117,21 +136,37 @@
       }
     }
 
-    tick(millis: number = 0, doTick?: (elapsed: number) => void): void {
+    tick(millis: number = 0, doTick?: (elapsed: number) => void, tickOptions: {
+      processNewMacroTasksSynchronously: boolean
+    } = {processNewMacroTasksSynchronously: true}): void {
       let finalTime = this._currentTime + millis;
       let lastCurrentTime = 0;
-      if (this._schedulerQueue.length === 0 && doTick) {
+      // we need to copy the schedulerQueue so nested timeout
+      // will not be wrongly called in the current tick
+      // https://github.com/angular/angular/issues/33799
+      const schedulerQueue = tickOptions.processNewMacroTasksSynchronously ?
+          this._schedulerQueue :
+          this._schedulerQueue.slice();
+      if (schedulerQueue.length === 0 && doTick) {
         doTick(millis);
         return;
       }
-      while (this._schedulerQueue.length > 0) {
-        let current = this._schedulerQueue[0];
+      while (schedulerQueue.length > 0) {
+        // clear requeueEntries before each loop
+        this._currentTickRequeuePeriodicEntries = [];
+        let current = schedulerQueue[0];
         if (finalTime < current.endTime) {
           // Done processing the queue since it's sorted by endTime.
           break;
         } else {
           // Time to run scheduled function. Remove it from the head of queue.
-          let current = this._schedulerQueue.shift() !;
+          let current = schedulerQueue.shift() !;
+          if (!tickOptions.processNewMacroTasksSynchronously) {
+            const idx = this._schedulerQueue.indexOf(current);
+            if (idx >= 0) {
+              this._schedulerQueue.splice(idx, 1);
+            }
+          }
           lastCurrentTime = this._currentTime;
           this._currentTime = current.endTime;
           if (doTick) {
@@ -143,6 +178,21 @@
             // Uncaught exception in the current scheduled function. Stop processing the queue.
             break;
           }
+
+          // check is there any requeue periodic entry is added in
+          // current loop, if there is, we need to add to current loop
+          if (!tickOptions.processNewMacroTasksSynchronously) {
+            this._currentTickRequeuePeriodicEntries.forEach(newEntry => {
+              let i = 0;
+              for (; i < schedulerQueue.length; i++) {
+                const currentEntry = schedulerQueue[i];
+                if (newEntry.endTime < currentEntry.endTime) {
+                  break;
+                }
+              }
+              schedulerQueue.splice(i, 0, newEntry);
+            });
+          }
         }
       }
       lastCurrentTime = this._currentTime;
@@ -274,7 +324,8 @@
       return () => {
         // Requeue the timer callback if it's not been canceled.
         if (this.pendingPeriodicTimers.indexOf(id) !== -1) {
-          this._scheduler.scheduleFunction(fn, interval, args, true, false, id);
+          this._scheduler.scheduleFunction(
+              fn, interval, {args, isPeriodic: true, id, isRequeuePeriodic: true});
         }
       };
     }
@@ -287,7 +338,8 @@
       let removeTimerFn = this._dequeueTimer(Scheduler.nextId);
       // Queue the callback and dequeue the timer on success and error.
       let cb = this._fnAndFlush(fn, {onSuccess: removeTimerFn, onError: removeTimerFn});
-      let id = this._scheduler.scheduleFunction(cb, delay, args, false, !isTimer);
+      let id =
+          this._scheduler.scheduleFunction(cb, delay, {args, isRequestAnimationFrame: !isTimer});
       if (isTimer) {
         this.pendingTimers.push(id);
       }
@@ -308,7 +360,7 @@
       completers.onSuccess = this._requeuePeriodicTimer(cb, interval, args, id);
 
       // Queue the callback and dequeue the periodic timer only on error.
-      this._scheduler.scheduleFunction(cb, interval, args, true);
+      this._scheduler.scheduleFunction(cb, interval, {args, isPeriodic: true});
       this.pendingPeriodicTimers.push(id);
       return id;
     }
@@ -380,10 +432,12 @@
       FakeAsyncTestZoneSpec.resetDate();
     }
 
-    tick(millis: number = 0, doTick?: (elapsed: number) => void): void {
+    tick(millis: number = 0, doTick?: (elapsed: number) => void, tickOptions: {
+      processNewMacroTasksSynchronously: boolean
+    } = {processNewMacroTasksSynchronously: true}): void {
       FakeAsyncTestZoneSpec.assertInZone();
       this.flushMicrotasks();
-      this._scheduler.tick(millis, doTick);
+      this._scheduler.tick(millis, doTick, tickOptions);
       if (this._lastError !== null) {
         this._resetLastErrorAndThrow();
       }
diff --git a/packages/zone.js/test/zone-spec/fake-async-test.spec.ts b/packages/zone.js/test/zone-spec/fake-async-test.spec.ts
index f538f6af88..6c7b82ed68 100644
--- a/packages/zone.js/test/zone-spec/fake-async-test.spec.ts
+++ b/packages/zone.js/test/zone-spec/fake-async-test.spec.ts
@@ -145,6 +145,22 @@ describe('FakeAsyncTestZoneSpec', () => {
          });
        }));
 
+    it('should not queue new macro task on tick with processNewMacroTasksSynchronously=false',
+       () => {
+         function nestedTimer(callback: () => any): void {
+           setTimeout(() => setTimeout(() => callback()));
+         }
+         fakeAsyncTestZone.run(() => {
+           const callback = jasmine.createSpy('callback');
+           nestedTimer(callback);
+           expect(callback).not.toHaveBeenCalled();
+           testZoneSpec.tick(0, null, {processNewMacroTasksSynchronously: false});
+           expect(callback).not.toHaveBeenCalled();
+           testZoneSpec.flush();
+           expect(callback).toHaveBeenCalled();
+         });
+       });
+
     it('should run queued timer after sufficient clock ticks', () => {
       fakeAsyncTestZone.run(() => {
         let ran = false;
diff --git a/tools/public_api_guard/core/testing.d.ts b/tools/public_api_guard/core/testing.d.ts
index 111156ec83..e443062de5 100644
--- a/tools/public_api_guard/core/testing.d.ts
+++ b/tools/public_api_guard/core/testing.d.ts
@@ -134,7 +134,9 @@ export declare type TestModuleMetadata = {
     aotSummaries?: () => any[];
 };
 
-export declare function tick(millis?: number): void;
+export declare function tick(millis?: number, tickOptions?: {
+    processNewMacroTasksSynchronously: boolean;
+}): void;
 
 export declare function withModule(moduleDef: TestModuleMetadata): InjectSetupWrapper;
 export declare function withModule(moduleDef: TestModuleMetadata, fn: Function): () => any;