diff --git a/packages/core/src/view/ng_module.ts b/packages/core/src/view/ng_module.ts
index 4a7d6a19ad..9e6bd20305 100644
--- a/packages/core/src/view/ng_module.ts
+++ b/packages/core/src/view/ng_module.ts
@@ -150,6 +150,15 @@ function _createProviderInstance(ngModule: NgModuleData, providerDef: NgModulePr
       injectable = providerDef.value;
       break;
   }
+
+  // The read of `ngOnDestroy` here is slightly expensive as it's megamorphic, so it should be
+  // avoided if possible. The sequence of checks here determines whether ngOnDestroy needs to be
+  // checked. It might not if the `injectable` isn't an object or if NodeFlags.OnDestroy is already
+  // set (ngOnDestroy was detected statically).
+  if (injectable !== UNDEFINED_VALUE && injectable != null && typeof injectable === 'object' &&
+      !(providerDef.flags & NodeFlags.OnDestroy) && typeof injectable.ngOnDestroy === 'function') {
+    providerDef.flags |= NodeFlags.OnDestroy;
+  }
   return injectable === undefined ? UNDEFINED_VALUE : injectable;
 }
 
@@ -199,12 +208,17 @@ function _callFactory(ngModule: NgModuleData, factory: any, deps: DepDef[]): any
 
 export function callNgModuleLifecycle(ngModule: NgModuleData, lifecycles: NodeFlags) {
   const def = ngModule._def;
+  const destroyed = new Set<any>();
   for (let i = 0; i < def.providers.length; i++) {
     const provDef = def.providers[i];
     if (provDef.flags & NodeFlags.OnDestroy) {
       const instance = ngModule._providers[i];
       if (instance && instance !== UNDEFINED_VALUE) {
-        instance.ngOnDestroy();
+        const onDestroy: Function|undefined = instance.ngOnDestroy;
+        if (typeof onDestroy === 'function' && !destroyed.has(instance)) {
+          onDestroy.apply(instance);
+          destroyed.add(instance);
+        }
       }
     }
   }
diff --git a/packages/core/test/view/ng_module_spec.ts b/packages/core/test/view/ng_module_spec.ts
index 4e89b95ae0..6e3c1fa9a1 100644
--- a/packages/core/test/view/ng_module_spec.ts
+++ b/packages/core/test/view/ng_module_spec.ts
@@ -101,6 +101,22 @@ function makeProviders(classes: any[], modules: any[]): NgModuleDefinition {
                     flags: NodeFlags.TypeClassProvider | NodeFlags.LazyProvider, token,
                     value: token,
                   }));
+  return makeModule(modules, providers);
+}
+
+function makeFactoryProviders(
+    factories: {token: any, factory: Function}[], modules: any[]): NgModuleDefinition {
+  const providers = factories.map((factory, index) => ({
+                                    index,
+                                    deps: [],
+                                    flags: NodeFlags.TypeFactoryProvider | NodeFlags.LazyProvider,
+                                    token: factory.token,
+                                    value: factory.factory,
+                                  }));
+  return makeModule(modules, providers);
+}
+
+function makeModule(modules: any[], providers: NgModuleProviderDef[]): NgModuleDefinition {
   const providersByKey: {[key: string]: NgModuleProviderDef} = {};
   providers.forEach(provider => providersByKey[tokenKey(provider.token)] = provider);
   return {factory: null, providers, providersByKey, modules, isRoot: true};
@@ -155,4 +171,58 @@ describe('NgModuleRef_ injector', () => {
 
   it('injects with the current injector always set',
      () => { expect(() => ref.injector.get(UsesInject)).not.toThrow(); });
+
+  it('calls ngOnDestroy on services created via factory', () => {
+    class Module {}
+
+    class Service {
+      static destroyed = 0;
+      ngOnDestroy(): void { Service.destroyed++; }
+    }
+
+    const ref = createNgModuleRef(
+        Module, Injector.NULL, [], makeFactoryProviders(
+                                       [{
+                                         token: Service,
+                                         factory: () => new Service(),
+                                       }],
+                                       [Module]));
+
+    expect(ref.injector.get(Service)).toBeDefined();
+    expect(Service.destroyed).toBe(0);
+    ref.destroy();
+    expect(Service.destroyed).toBe(1);
+  });
+
+  it('only calls ngOnDestroy once per instance', () => {
+    class Module {}
+
+    class Service {
+      static destroyed = 0;
+      ngOnDestroy(): void { Service.destroyed++; }
+    }
+
+    class OtherToken {}
+
+    const instance = new Service();
+    const ref = createNgModuleRef(
+        Module, Injector.NULL, [], makeFactoryProviders(
+                                       [
+                                         {
+                                           token: Service,
+                                           factory: () => instance,
+                                         },
+                                         {
+                                           token: OtherToken,
+                                           factory: () => instance,
+                                         }
+                                       ],
+                                       [Module]));
+
+    expect(ref.injector.get(Service)).toBe(instance);
+    expect(ref.injector.get(OtherToken)).toBe(instance);
+    expect(Service.destroyed).toBe(0);
+    ref.destroy();
+    expect(Service.destroyed).toBe(1);
+  });
 });