diff --git a/packages/compiler-cli/src/ngtsc/program.ts b/packages/compiler-cli/src/ngtsc/program.ts
index 7b73608579..8d311901d7 100644
--- a/packages/compiler-cli/src/ngtsc/program.ts
+++ b/packages/compiler-cli/src/ngtsc/program.ts
@@ -11,6 +11,7 @@ import * as path from 'path';
 import * as ts from 'typescript';
 
 import * as api from '../transformers/api';
+import {nocollapseHack} from '../transformers/nocollapse_hack';
 
 import {ComponentDecoratorHandler, DirectiveDecoratorHandler, InjectableDecoratorHandler, NgModuleDecoratorHandler, PipeDecoratorHandler, ResourceLoader, SelectorScopeRegistry} from './annotations';
 import {BaseDefDecoratorHandler} from './annotations/src/base_def';
@@ -30,6 +31,7 @@ export class NgtscProgram implements api.Program {
   private _reflector: TypeScriptReflectionHost|undefined = undefined;
   private _isCore: boolean|undefined = undefined;
   private rootDirs: string[];
+  private closureCompilerEnabled: boolean;
 
 
   constructor(
@@ -43,6 +45,7 @@ export class NgtscProgram implements api.Program {
     } else {
       this.rootDirs.push(host.getCurrentDirectory());
     }
+    this.closureCompilerEnabled = !!options.annotateForClosureCompiler;
     this.resourceLoader = host.readResource !== undefined ?
         new HostResourceLoader(host.readResource.bind(host)) :
         new FileResourceLoader();
@@ -156,6 +159,8 @@ export class NgtscProgram implements api.Program {
           if (fileName.endsWith('.d.ts')) {
             data = sourceFiles.reduce(
                 (data, sf) => this.compilation !.transformedDtsFor(sf.fileName, data), data);
+          } else if (this.closureCompilerEnabled && fileName.endsWith('.ts')) {
+            data = nocollapseHack(data);
           }
           this.host.writeFile(fileName, data, writeByteOrderMark, onError, sourceFiles);
         };
diff --git a/packages/compiler-cli/src/transformers/nocollapse_hack.ts b/packages/compiler-cli/src/transformers/nocollapse_hack.ts
new file mode 100644
index 0000000000..92fb1e1b99
--- /dev/null
+++ b/packages/compiler-cli/src/transformers/nocollapse_hack.ts
@@ -0,0 +1,58 @@
+/**
+ * @license
+ * Copyright Google Inc. All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.io/license
+ */
+
+// Closure compiler transforms the form `Service.ngInjectableDef = X` into
+// `Service$ngInjectableDef = X`. To prevent this transformation, such assignments need to be
+// annotated with @nocollapse. Unfortunately, a bug in Typescript where comments aren't propagated
+// through the TS transformations precludes adding the comment via the AST. This workaround detects
+// the static assignments to R3 properties such as ngInjectableDef using a regex, as output files
+// are written, and applies the annotation through regex replacement.
+//
+// TODO(alxhub): clean up once fix for TS transformers lands in upstream
+//
+// Typescript reference issue: https://github.com/Microsoft/TypeScript/issues/22497
+
+// Pattern matching all Render3 property names.
+const R3_DEF_NAME_PATTERN = [
+  'ngBaseDef',
+  'ngComponentDef',
+  'ngDirectiveDef',
+  'ngInjectableDef',
+  'ngInjectorDef',
+  'ngModuleDef',
+  'ngPipeDef',
+].join('|');
+
+// Pattern matching `Identifier.property` where property is a Render3 property.
+const R3_DEF_ACCESS_PATTERN = `[^\\s\\.()[\\]]+\.(${R3_DEF_NAME_PATTERN})`;
+
+// Pattern matching a source line that contains a Render3 static property assignment.
+// It declares two matching groups - one for the preceding whitespace, the second for the rest
+// of the assignment expression.
+const R3_DEF_LINE_PATTERN = `^(\\s*)(${R3_DEF_ACCESS_PATTERN} = .*)$`;
+
+// Regex compilation of R3_DEF_LINE_PATTERN. Matching group 1 yields the whitespace preceding the
+// assignment, matching group 2 gives the rest of the assignment expressions.
+const R3_MATCH_DEFS = new RegExp(R3_DEF_LINE_PATTERN, 'gmu');
+
+const R3_TSICKLE_DECL_PATTERN =
+    `(\\/\\*\\*[*\\s]*)(@[^*]+\\*\\/\\s+[^.]+\\.(?:${R3_DEF_NAME_PATTERN});)`;
+
+const R3_MATCH_TSICKLE_DECL = new RegExp(R3_TSICKLE_DECL_PATTERN, 'gmu');
+
+// Replacement string that complements R3_MATCH_DEFS. It inserts `/** @nocollapse */` before the
+// assignment but after any indentation. Note that this will mess up any sourcemaps on this line
+// (though there shouldn't be any, since Render3 properties are synthetic).
+const R3_NOCOLLAPSE_DEFS = '$1\/** @nocollapse *\/ $2';
+
+const R3_NOCOLLAPSE_TSICKLE_DECL = '$1@nocollapse $2';
+
+export function nocollapseHack(contents: string): string {
+  return contents.replace(R3_MATCH_DEFS, R3_NOCOLLAPSE_DEFS)
+      .replace(R3_MATCH_TSICKLE_DECL, R3_NOCOLLAPSE_TSICKLE_DECL);
+}
diff --git a/packages/compiler-cli/src/transformers/program.ts b/packages/compiler-cli/src/transformers/program.ts
index 72864ecc58..8315f0e1a5 100644
--- a/packages/compiler-cli/src/transformers/program.ts
+++ b/packages/compiler-cli/src/transformers/program.ts
@@ -22,6 +22,7 @@ import {CodeGenerator, TsCompilerAotCompilerTypeCheckHostAdapter, getOriginalRef
 import {InlineResourcesMetadataTransformer, getInlineResourcesTransformFactory} from './inline_resources';
 import {LowerMetadataTransform, getExpressionLoweringTransformFactory} from './lower_expressions';
 import {MetadataCache, MetadataTransformer} from './metadata_cache';
+import {nocollapseHack} from './nocollapse_hack';
 import {getAngularEmitterTransformFactory} from './node_emitter_transform';
 import {PartialModuleMetadataTransformer} from './r3_metadata_transform';
 import {StripDecoratorsMetadataTransformer, getDecoratorStripTransformerFactory} from './r3_strip_decorators';
@@ -30,37 +31,6 @@ import {TscPassThroughProgram} from './tsc_pass_through';
 import {DTS, GENERATED_FILES, StructureIsReused, TS, createMessageDiagnostic, isInRootDir, ngToTsDiagnostic, tsStructureIsReused, userError} from './util';
 
 
-// Closure compiler transforms the form `Service.ngInjectableDef = X` into
-// `Service$ngInjectableDef = X`. To prevent this transformation, such assignments need to be
-// annotated with @nocollapse. Unfortunately, a bug in Typescript where comments aren't propagated
-// through the TS transformations precludes adding the comment via the AST. This workaround detects
-// the static assignments to R3 properties such as ngInjectableDef using a regex, as output files
-// are written, and applies the annotation through regex replacement.
-//
-// TODO(alxhub): clean up once fix for TS transformers lands in upstream
-//
-// Typescript reference issue: https://github.com/Microsoft/TypeScript/issues/22497
-
-// Pattern matching all Render3 property names.
-const R3_DEF_NAME_PATTERN = ['ngInjectableDef'].join('|');
-
-// Pattern matching `Identifier.property` where property is a Render3 property.
-const R3_DEF_ACCESS_PATTERN = `[^\\s\\.()[\\]]+\.(${R3_DEF_NAME_PATTERN})`;
-
-// Pattern matching a source line that contains a Render3 static property assignment.
-// It declares two matching groups - one for the preceding whitespace, the second for the rest
-// of the assignment expression.
-const R3_DEF_LINE_PATTERN = `^(\\s*)(${R3_DEF_ACCESS_PATTERN} = .*)$`;
-
-// Regex compilation of R3_DEF_LINE_PATTERN. Matching group 1 yields the whitespace preceding the
-// assignment, matching group 2 gives the rest of the assignment expressions.
-const R3_MATCH_DEFS = new RegExp(R3_DEF_LINE_PATTERN, 'gmu');
-
-// Replacement string that complements R3_MATCH_DEFS. It inserts `/** @nocollapse */` before the
-// assignment but after any indentation. Note that this will mess up any sourcemaps on this line
-// (though there shouldn't be any, since Render3 properties are synthetic).
-const R3_NOCOLLAPSE_DEFS = '$1\/** @nocollapse *\/ $2';
-
 /**
  * Maximum number of files that are emitable via calling ts.Program.emit
  * passing individual targetSourceFiles.
@@ -300,10 +270,6 @@ class AngularCompilerProgram implements Program {
                                              this._emitRender2(parameters);
   }
 
-  private _annotateR3Properties(contents: string): string {
-    return contents.replace(R3_MATCH_DEFS, R3_NOCOLLAPSE_DEFS);
-  }
-
   private _emitRender3(
       {
           emitFlags = EmitFlags.Default, cancellationToken, customTransformers,
@@ -332,7 +298,7 @@ class AngularCompilerProgram implements Program {
           let genFile: GeneratedFile|undefined;
           if (this.options.annotateForClosureCompiler && sourceFile &&
               TS.test(sourceFile.fileName)) {
-            outData = this._annotateR3Properties(outData);
+            outData = nocollapseHack(outData);
           }
           this.writeFile(outFileName, outData, writeByteOrderMark, onError, undefined, sourceFiles);
         };
@@ -425,7 +391,7 @@ class AngularCompilerProgram implements Program {
               }
             }
             if (this.options.annotateForClosureCompiler && TS.test(sourceFile.fileName)) {
-              outData = this._annotateR3Properties(outData);
+              outData = nocollapseHack(outData);
             }
           }
           this.writeFile(outFileName, outData, writeByteOrderMark, onError, genFile, sourceFiles);
diff --git a/packages/compiler-cli/test/transformers/nocollapse_hack_spec.ts b/packages/compiler-cli/test/transformers/nocollapse_hack_spec.ts
new file mode 100644
index 0000000000..095fe8af59
--- /dev/null
+++ b/packages/compiler-cli/test/transformers/nocollapse_hack_spec.ts
@@ -0,0 +1,26 @@
+/**
+ * @license
+ * Copyright Google Inc. All Rights Reserved.
+ *
+ * Use of this source code is governed by an MIT-style license that can be
+ * found in the LICENSE file at https://angular.io/license
+ */
+
+import {nocollapseHack} from '../../src/transformers/nocollapse_hack';
+
+describe('@nocollapse hack', () => {
+  it('should add @nocollapse to a basic class', () => {
+    const decl = `Foo.ngInjectorDef = define(...);`;
+    expect(nocollapseHack(decl)).toEqual('/** @nocollapse */ ' + decl);
+  });
+
+  it('should add nocollapse to an if (false) declaration of the kind generated by tsickle', () => {
+    const decl = `
+      if (false) {
+        /** @type {?} */
+        Foo.ngInjectorDef;
+      }
+    `;
+    expect(nocollapseHack(decl)).toContain('/** @nocollapse @type {?} */');
+  });
+});
\ No newline at end of file