diff --git a/packages/compiler-cli/ngcc/src/rendering/umd_rendering_formatter.ts b/packages/compiler-cli/ngcc/src/rendering/umd_rendering_formatter.ts
index f15e23b581..e34c1c70b8 100644
--- a/packages/compiler-cli/ngcc/src/rendering/umd_rendering_formatter.ts
+++ b/packages/compiler-cli/ngcc/src/rendering/umd_rendering_formatter.ts
@@ -204,15 +204,21 @@ function isAmdConditional(value: ts.Node): value is AmdConditional {
  */
 function isGlobalFactoryCall(value: ts.Node): value is ts.CallExpression {
   if (ts.isCallExpression(value) && !!value.parent) {
+    // Be resilient to the value being part of a comma list
+    value = isCommaExpression(value.parent) ? value.parent : value;
     // Be resilient to the value being inside parentheses
-    const expression = ts.isParenthesizedExpression(value.parent) ? value.parent : value;
-    return !!expression.parent && ts.isConditionalExpression(expression.parent) &&
-        expression.parent.whenFalse === expression;
+    value = ts.isParenthesizedExpression(value.parent) ? value.parent : value;
+    return !!value.parent && ts.isConditionalExpression(value.parent) &&
+        value.parent.whenFalse === value;
   } else {
     return false;
   }
 }
 
+function isCommaExpression(value: ts.Node): value is ts.BinaryExpression {
+  return ts.isBinaryExpression(value) && value.operatorToken.kind === ts.SyntaxKind.CommaToken;
+}
+
 function getGlobalIdentifier(i: Import) {
   return i.specifier.replace('@angular/', 'ng.').replace(/^\//, '');
 }
diff --git a/packages/compiler-cli/ngcc/test/rendering/umd_rendering_formatter_spec.ts b/packages/compiler-cli/ngcc/test/rendering/umd_rendering_formatter_spec.ts
index 3031094985..c67c5d5d7f 100644
--- a/packages/compiler-cli/ngcc/test/rendering/umd_rendering_formatter_spec.ts
+++ b/packages/compiler-cli/ngcc/test/rendering/umd_rendering_formatter_spec.ts
@@ -50,10 +50,21 @@ runInEachFileSystem(() => {
     let _: typeof absoluteFrom;
     let PROGRAM: TestFile;
     let PROGRAM_DECORATE_HELPER: TestFile;
+    let PROGRAM_WITH_GLOBAL_INITIALIZER: TestFile;
 
     beforeEach(() => {
       _ = absoluteFrom;
 
+      PROGRAM_WITH_GLOBAL_INITIALIZER = {
+        name: _('/node_modules/test-package/some/file.js'),
+        contents: `
+        (function (global, factory) {
+          typeof exports === 'object' && typeof module !== 'undefined' ? factory(exports,require('some-side-effect'),require('/local-dep'),require('@angular/core')) :
+          typeof define === 'function' && define.amd ? define('file', ['exports','some-side-effect','/local-dep','@angular/core'], factory) :
+          (global = global || self, factory(global.file,global.someSideEffect,global.localDep,global.ng.core));
+          }(this, (function (exports,someSideEffect,localDep,core) {'use strict'; })));`
+      };
+
       PROGRAM = {
         name: _('/node_modules/test-package/some/file.js'),
         contents: `
@@ -228,6 +239,22 @@ typeof define === 'function' && define.amd ? define('file', ['exports','/tslib',
                 `(factory(global.file,global.someSideEffect,global.localDep,global.ng.core,global.ng.core,global.ng.common));`);
       });
 
+      it('should append the given imports into the global initialization, if it has a global/self initializer',
+         () => {
+           const {renderer, program} = setup(PROGRAM_WITH_GLOBAL_INITIALIZER);
+           const file = getSourceFileOrError(program, _('/node_modules/test-package/some/file.js'));
+           const output = new MagicString(file.text);
+           renderer.addImports(
+               output,
+               [
+                 {specifier: '@angular/core', qualifier: 'i0'},
+                 {specifier: '@angular/common', qualifier: 'i1'}
+               ],
+               file);
+           expect(output.toString())
+               .toContain(
+                   `(global = global || self, factory(global.file,global.someSideEffect,global.localDep,global.ng.core,global.ng.core,global.ng.common));`);
+         });
       it('should append the given imports as parameters into the factory function definition',
          () => {
            const {renderer, program} = setup(PROGRAM);